反应 #53826

ord-eaf1321dd68245f4a6ee218ecd93300d

反应方程式

CN[C@H]1CC[C@H](O)CC1
trans-4-Methylamino-cyclohexanol
O=S(=O)(Cl)c1ccc(Br)cc1
4-bromobenzenesulfonylchloride
→
CN([C@H]1CC[C@H](O)CC1)S(=O)(=O)c1ccc(Br)cc1
trans-4-Bromo-N-(4-hydroxy-cyclohexyl)-N-methyl-benzenesulfonamide

反应物

CN[C@H]1CC[C@H](O)CC1
trans-4-Methylamino-cyclohexanol
O=S(=O)(Cl)c1ccc(Br)cc1
4-bromobenzenesulfonylchloride

试剂

无

反应条件

详细条件
See reaction.notes.procedure_details.

实验过程

In analogy to example 11.9. trans-4-Methylamino-cyclohexanol and 4-bromobenzenesulfonylchloride were reacted to yield trans-4-Bromo-N-(4-hydroxy-cyclohexyl)-N-methyl-benzenesulfonamide as off-white solid, MS: 348 (MH+, 1Br).

来源

DOI: 10.6084/m9.figshare.5104873.v1专利: US06858651B2uspto-grants-2005_02