反应 #531804

反应方程式

Acetic acid

4-pentynoic acid

N-hydroxy succinimide

DCC

→

10a

收率 100.5%

Pent-4-ynoic acid 2,5-dioxo-pyrrolidin-1-yl ester

收率 100.5%

溶剂

THF

反应条件

后处理

1. 1
   workup.WAITthen left
2. 2
   workup.STIRRINGto stir at room temperature overnight
3. 3
   workup.WAIT(A white precipitate was observed after 15 min
4. 4
   其他The resulting DCU was removed by filtration
5. 5
   其他The filtrate was then evaporated

实验过程

4-pentynoic acid (5.0 g, 51 mmol) and N-hydroxy succinimide (5.87 g, 51 mmol) were added to a solution of DCC (12.6 g, 61.2 mmol) in THF (125 ml) at −10° C. The mixture was then stirred for 1 h at −10° C. then left to stir at room temperature overnight. (A white precipitate was observed after 15 min). Acetic acid (0.63 ml) was then added. The resulting DCU was removed by filtration. The filtrate was then evaporated to give 10a (10 g, 100% crude yield).

来源