反应 #531803

反应方程式

4c

N-(Tris(3-benzyloxy-4-oxo-4H-pyran-2-yl)carboxyaminopropyl)methyl benzamide

→

title compound 6

收率 114.7%

N-(Tris(-3-hydroxy-4-oxo-4H-pyran-2-yl)carboxyaminopropyl)methyl benzamide

收率 114.7%

溶剂

acetic acid

hydrochloric acid

反应条件

后处理

1. 1
   浓缩The reaction mixture was concentrated in vacuo
2. 2
   其他the residue azeotroped several times with methanol (10 ml)

实验过程

A solution of 4c (0.20 g, 0.20 mmol) in glacial acetic acid (2 ml) and concentrated hydrochloric acid (2 ml) was stirred at room temperature for 18 h. The reaction mixture was concentrated in vacuo, the residue azeotroped several times with methanol (10 ml) to afford the title compound 6 (130 mg, 90%) as a red-orange solid.

来源