反应 #53180

ord-be67a9f166cc40a6bc7d98a3d68a96a4

反应方程式

CC(=O)N1C(=O)/C(=C(\Nc2ccc(NS(=O)(=O)c3ccc(C)cc3)cc2)c2ccccc2)c2cc([N+](=O)[O-])ccc21
(Z)-1-acetyl-3-{1-[4-(p-tolylsulphonylamino)-phenylamino]-1-phenyl-methylidene}-5-nitro-2-indolinone
CN(C)C(=O)CBr
bromoacetic acid-N,N-dimethylamide
CC(C)(C)[O-].[K+]
potassium tert.butoxide
[Na+].[OH-]
sodium hydroxide
→
Cc1ccc(S(=O)(=O)N(CC(=O)N(C)C)c2ccc(N/C(=C3\C(=O)Nc4ccc([N+](=O)[O-])cc43)c3ccccc3)cc2)cc1
(Z)-3-{1-[4-(N-dimethylaminocarbonylmethyl-N-(p-tolylsulphonyl)-amino)-phenylamino]-1-phenyl-methylidene}-5-nitro-2-indolinone

反应物

CC(=O)N1C(=O)/C(=C(\Nc2ccc(NS(=O)(=O)c3ccc(C)cc3)cc2)c2ccccc2)c2cc([N+](=O)[O-])ccc21
(Z)-1-acetyl-3-{1-[4-(p-tolylsulphonylamino)-phenylamino]-1-phenyl-methylidene}-5-nitro-2-indolinone
CN(C)C(=O)CBr
bromoacetic acid-N,N-dimethylamide
CC(C)(C)[O-].[K+]
potassium tert.butoxide
[Na+].[OH-]
sodium hydroxide

试剂

无

溶剂

CS(C)=O
DMSO
CO
methanol

反应条件

详细条件
See reaction.notes.procedure_details.

实验过程

Prepared analogously to Examples 82 and 187 from (Z)-1-acetyl-3-{1-[4-(p-tolylsulphonylamino)-phenylamino]-1-phenyl-methylidene}-5-nitro-2-indolinone, bromoacetic acid-N,N-dimethylamide and potassium tert.butoxide in DMSO and subsequent treatment with sodium hydroxide solution in methanol.

来源

DOI: 10.6084/m9.figshare.5104873.v1专利: US06855710B2uspto-grants-2005_02