反应 #531796

反应方程式

compound 25

N-(11-(p-tolyloxy)undecyl)-3-(tritylthio)propaneamide

trifluoroacetic acid

triethylsilane

→

N-(11-(p-tolyloxy)undecyl)-3-mercaptopropaneamide

溶剂

methylene chloride

methylene chloride

反应条件

后处理

1. 1
   其他to obtain a brown-colored solution
2. 2
   workup.DISTILLATIONthe supernatant solution was distilled away under reduced pressure
3. 3
   其他The solid obtained
4. 4
   洗涤was washed twice with 30 ml of aqueous saturated sodium hydrogen carbonate solution and twice with 30 ml of saturated brine
5. 5
   其他the desiccant agent was removed by filtration
6. 6
   workup.DISTILLATIONthe solvent of the filtrate was distilled away under reduced pressure
7. 7
   其他The reaction mixture was purified by chromatography, and 0.1 g of the compound f, which
8. 8
   其他was obtained

实验过程

The compound 25 (0.181 g) was dissolved in 1 ml of methylene chloride, and 0.5 ml of trifluoroacetic acid was added to that while being stirred, to obtain a brown-colored solution. After a white-colored precipitate was generated by adding 0.16 ml of triethylsilane, the supernatant solution was distilled away under reduced pressure. The solid obtained was dissolved by the new addition of 20 ml of methylene chloride, and was washed twice with 30 ml of aqueous saturated sodium hydrogen carbonate solution and twice with 30 ml of saturated brine. After the collected organic phase was dehydrated with magnesium sulfate, the desiccant agent was removed by filtration, and the solvent of the filtrate was distilled away under reduced pressure. The reaction mixture was purified by chromatography, and 0.1 g of the compound f, which was a white solid, was obtained.

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