反应 #531790

反应方程式

Mercaptopropionic acid

Triphenylmethylchloride

→

3-(tritylthio)propanoic acid

收率 95.7%

3-(tritylthio) propanoic acid

收率 95.7%

溶剂

methylene chloride

反应条件

后处理

1. 1
   其他were carried out at room temperature
2. 2
   过滤was filtered
3. 3
   洗涤was rinsed with 40 ml of diethyl ether
4. 4
   其他The precipitate was then dried under reduced pressure

实验过程

Mercaptopropionic acid 2 (3.14 g) was dissolved in 50 ml of methylene chloride. Triphenylmethylchloride 3 (8.36 g, 30 mmol) was added to that, and 19-hour protection reactions were carried out at room temperature. The precipitate generated through the protection reactions was filtered and gathered, and was rinsed with 40 ml of diethyl ether. The precipitate was then dried under reduced pressure, to form 9.86 g of 3-(tritylthio)propanoic acid 4, which is a white solid.

来源