反应 #53179

ord-c1e58ccacf284affa8f5bc6c466b275e

反应方程式

$CC(=O)N1C(=O)/C(=C(\Nc2ccc(NS(=O)(=O)c3ccccc3)cc2)c2ccccc2)c2cc([N+](=O)[O-])ccc21$

(Z)-1-acetyl-3-[1-(4-phenylsulphonylamino-phenylamino)-1-phenyl-methylidene]-5-nitro-2-indolinone

bromoacetic acid-N,N-dimethylamide

potassium tert.butoxide

sodium hydroxide

→

$CN(C)C(=O)CN(c1ccc(N/C(=C2\C(=O)Nc3ccc([N+](=O)[O-])cc32)c2ccccc2)cc1)S(=O)(=O)c1ccccc1$

(Z)-3-{1-[4-(N-dimethylaminocarbonylmethyl-N-phenylsulphonyl-amino)-phenylamino]-1-phenyl-methylidene}-5-nitro-2-indolinone

反应物

$CC(=O)N1C(=O)/C(=C(\Nc2ccc(NS(=O)(=O)c3ccccc3)cc2)c2ccccc2)c2cc([N+](=O)[O-])ccc21$

(Z)-1-acetyl-3-[1-(4-phenylsulphonylamino-phenylamino)-1-phenyl-methylidene]-5-nitro-2-indolinone

bromoacetic acid-N,N-dimethylamide

potassium tert.butoxide

sodium hydroxide

试剂

无

溶剂

DMSO

methanol

反应条件

详细条件

See reaction.notes.procedure_details.

实验过程

Prepared analogously to Examples 82 and 187 from (Z)-1-acetyl-3-[1-(4-phenylsulphonylamino-phenylamino)-1-phenyl-methylidene]-5-nitro-2-indolinone, bromoacetic acid-N,N-dimethylamide and potassium tert.butoxide in DMSO and subsequent treatment with sodium hydroxide solution in methanol.

来源

DOI: 10.6084/m9.figshare.5104873.v1专利: US06855710B2uspto-grants-2005_02