反应 #531786

反应方程式

water

4-aminobenzyl cyanide

pyridine

chloride

→

desired product

N-(4-cyanomethylphenyl) p-menthanecarboxamide

反应条件

后处理

1. 1
   其他The mixture was separated
2. 2
   洗涤The organic layer was washed with 50 mL of water and 50 mL of brine
3. 3
   干燥The organic layer was dried over MgSO4
4. 4
   其他The solvent was evaporated in vacuo
5. 5
   其他to afford the crude product, which
6. 6
   其他was recrystallized from hexanes

实验过程

To a flask, were added 6.6 g (50 mmol) of 4-aminobenzyl cyanide, 4.04 mL of pyridine and 100 mL MtBE. To this mixture, 10 g of p-menthane-3-carbon*yl chloride were added dropwise over 5 minutes. The reaction mixture was stirred for 24 h. To the reaction mixture, 50 mL of water were added. The mixture was separated. The organic layer was washed with 50 mL of water and 50 mL of brine. The organic layer was dried over MgSO4. The solvent was evaporated in vacuo to afford the crude product, which was recrystallized from hexanes to afford 10.1 g of the desired product with the following spectroscopic properties:

来源