反应 #5313

反应方程式

4-Methoxybenzeneethanol

1,6-dibromohexane

NaOH

→

oil

1-[2-[(6-Bromohexyl)oxy]ethyl]-4-methoxybenzene

溶剂

H2O

反应条件

后处理

1. 1
   萃取extracted with ER (3×150 ml)
2. 2
   洗涤the combined organic extracts were washed consecutively with H2O (125 ml), BR (125 ml)
3. 3
   其他dried
4. 4
   其他evaporated

实验过程

4-Methoxybenzeneethanol (5.0 g) and 1,6-dibromohexane (23.7 g) were stirred rapidly at RT with tetra-n-butyl ammonium bisulphate (0.94 g) and 12.5 M aqueous NaOH (30 ml) for 16 h. The mixture was diluted with H2O (125 ml), extracted with ER (3×150 ml) and the combined organic extracts were washed consecutively with H2O (125 ml), BR (125 ml), dried and evaporated to give an oil (24.6 g). The oil was purified by [FCS] eluting with ER-CX (0:100→4:96) to give the title compound as a colourless oil (8.30 g). T.l.c. (CX-ER (40:1)) Rf 0.33.

来源