反应 #52993

反应方程式

4-amino-2-chlorobenzoic acid methyl ester

2-chloroethylisothiocyanate

→

2-chloro-4-(2-thiazolinylamino)benzoic acid methyl ester

溶剂

THF

反应条件

后处理

1. 1
   温度was refluxed for 24 h
2. 2
   workup.DISTILLATIONTHF was distilled
3. 3
   其他the residue was purified by column chromatography (silica gel: eluent: hexane/EtOAc 3:1-1:1)

实验过程

A mixture of 4-amino-2-chlorobenzoic acid methyl ester (0.5 g) and 2-chloroethylisothiocyanate (0.26 mL) in THF (20 mL) was refluxed for 24 h. THF was distilled and the residue was purified by column chromatography (silica gel: eluent: hexane/EtOAc 3:1-1:1) to yield 2-chloro-4-(2-thiazolinylamino)benzoic acid methyl ester (74 mg). ESMS: m/z 271 (MH+).

来源