反应 #52925

反应方程式

NaBH4

N-(2,6-dichlorobenzoyl)-4-(2-formylphenyl)-L-phenylalanine methyl ester

→

N-(2,6-dichlorobenzoyl)-4-[2-(hydroxymethyl)phenyl]-L-phenylalanine methyl ester

收率 103.9%

溶剂

MeOH

反应条件

后处理

1. 1
   其他The reaction was quenched with acetone
2. 2
   其他the mixture was evaporated
3. 3
   其他The residue was partitioned between EtOAc and water
4. 4
   干燥The EtOAc layer was dried (MgSO4)
5. 5
   其他evaporated

实验过程

NaBH4 (21 mg) was added to a solution of N-(2,6-dichlorobenzoyl)-4-(2-formylphenyl)-L-phenylalanine methyl ester (0.23 g) in MeOH (5 mL) and the mixture was stirred at room temperature for 3 h. The reaction was quenched with acetone and the mixture was evaporated. The residue was partitioned between EtOAc and water. The EtOAc layer was dried (MgSO4) and evaporated to yield N-(2,6-dichlorobenzoyl)-4-[2-(hydroxymethyl)phenyl]-L-phenylalanine methyl ester (0.24 g). ESMS: m/z 480 ([M+Na]+).

来源