反应 #52805

反应方程式

Acetic acid

(2-Formyl-4,5,6,7-tetrahydro-1H-indol-3-yl)-propionic acid

5-bromo-4-methyl-2-oxindole

piperidine

→

3-[2-(5-bromo-4-methyl-2-oxo-1,2-dihydroindol-3-ylidenemethyl)-4,5,6,7-tetrahydro-1H-indol-3-yl]-propionic acid

收率 80.0%

溶剂

ethanol

反应条件

后处理

1. 1
   温度was refluxed for 4 hours
2. 2
   其他a precipitate formed
3. 3
   温度The mixture was refluxed for 5 minutes
4. 4
   过滤The precipitate was collected by vacuum filtration
5. 5
   洗涤washed with 20 mL of ethanol
6. 6
   洗涤The solids were slurry-washed in 30 mL of refluxing ethanol
7. 7
   温度cooled
8. 8
   过滤collected by vacuum filtration
9. 9
   洗涤washed with 30 mL of ethanol and vacuum
10. 10
    其他dried

实验过程

A mixture of (2-Formyl-4,5,6,7-tetrahydro-1H-indol-3-yl)-propionic acid (5.4 g), 5.0 g of 5-bromo-4-methyl-2-oxindole and 2.7 g of piperidine in 25 mL of ethanol was refluxed for 4 hours. Acetic acid (8 mL) was slowly added and a precipitate formed. The mixture was refluxed for 5 minutes and cooled to ambient temperature. The precipitate was collected by vacuum filtration and washed with 20 mL of ethanol. The solids were slurry-washed in 30 mL of refluxing ethanol, cooled, collected by vacuum filtration, washed with 30 mL of ethanol and vacuum dried to give 7.6 g (80%) of 3-[2-(5-bromo-4-methyl-2-oxo-1,2-dihydroindol-3-ylidenemethyl)-4,5,6,7-tetrahydro-1H-indol-3-yl]-propionic acid as an red-orange solid.

来源