反应 #52793

反应方程式

6-(3-methoxyphenyl)-2-oxindole

3-(2-formyl-4,5,6,7-tetrahydro-1H-indol-3-yl)-propionic acid

→

3-{2-[6-(3-methoxyphenyl)-2-oxo-1,2-dihydroindol-3-ylidenemethyl]-4,5,6,7-tetrahydro-1H-indol-3-yl}-propionic acid

收率 82.1%

溶剂

ethanol

反应条件

后处理

1. 1
   浓缩The reaction mixture was concentrated
2. 2
   其他The precipitate that formed
3. 3
   过滤was collected by filtration
4. 4
   洗涤washed with water and hexane

实验过程

A mixture of 103 mg 6-(3-methoxyphenyl)-2-oxindole, 95 mg 3-(2-formyl-4,5,6,7-tetrahydro-1H-indol-3-yl)-propionic acid and piperidine (3 drops) in ethanol (2 mL) was heated in sealed tube to 90° C. and held there overnight. The reaction mixture was concentrated and acidified with 6 N hydrochloric acid. The precipitate that formed was collected by filtration and washed with water and hexane to give 156 mg of 3-{2-[6-(3-methoxyphenyl)-2-oxo-1,2-dihydroindol-3-ylidenemethyl]-4,5,6,7-tetrahydro-1H-indol-3-yl}-propionic acid as a brown solid (82%).

来源