反应 #5259

反应方程式

potassium hydroxide

10-iododecyl allyl ether

methyl p-hydroxybenzoate

potassium carbonate

hydrochloric acid

→

4-(10-allyloxydecyloxy)benzoic acid

收率 80.0%

溶剂

ethanol

反应条件

后处理

1. 1
   其他After conclusion of the reaction
2. 2
   其他the acidified reaction solution
3. 3
   浓缩was then concentrated under reduced pressure
4. 4
   workup.ADDITIONWater was added to the residue
5. 5
   其他to form a suspension
6. 6
   其他the insoluble matter was collected
7. 7
   其他was then dried

实验过程

70 mmol (22.7 g) of 10-iododecyl allyl ether, 70 mmol (10.6 g) of methyl p-hydroxybenzoate, and 70 mmol (9.6 g) of potassium carbonate were refluxed in absolute ethanol for 15 hours. After addition of an aqueous potassium hydroxide solution (containing 4.0 g of potassium hydroxide) into the reaction solution, the resulting mixture was further heated at 80° C. for 5 hours. After conclusion of the reaction, the reaction solution was acidified with hydrochloric acid, and the acidified reaction solution was then concentrated under reduced pressure. Water was added to the residue to form a suspension, and the insoluble matter was collected and was then dried, to obtain 18.7 g of 4-(10-allyloxydecyloxy)benzoic acid (Yield: 80%).

来源