反应 #5256

反应方程式

7-amino-cephalosporanic acid

boron trifluoride

isopropanol

→

3-isopropoxymethyl-7-amino-ceph-3-eme-4-carboxylic acid

溶剂

triethylamine

反应条件

后处理

1. 1
   其他were reacted
2. 2
   其他to obtain 16.25 g of raw product which
3. 3
   其他was purified by two successive treatments with hot hydrochloric acid and ammonium hydroxide

实验过程

Using the procedure of Step A of Example 8, 27.2 g of 7-amino-cephalosporanic acid, 170 ml of the etherate of boron trifluoride, 134 ml of isopropanol and 125 ml of triethylamine were reacted to obtain 16.25 g of raw product which was purified by two successive treatments with hot hydrochloric acid and ammonium hydroxide to obtain 5.8 g of 3-isopropoxymethyl-7-amino-ceph-3-eme-4-carboxylic acid.

来源