反应 #5255

反应方程式

7-amino-cephalosporanic acid

boron trifluoride

propanol

→

3-propoxymethyl-7-amino-ceph-3-eme-4-carboxylic acid

溶剂

triethylamine

反应条件

后处理

1. 1
   其他were reacted
2. 2
   其他to obtain 17.4 g of raw product which
3. 3
   其他was purified with hot hydrochloric acid and ammonium hydroxide

实验过程

Using the procedure of Step A of Example 8, 27.2 g of 7-amino-cephalosporanic acid, 170 ml of the etherate of of boron trifluoride, 131 ml of propanol and 128 ml of triethylamine were reacted to obtain 17.4 g of raw product which was purified with hot hydrochloric acid and ammonium hydroxide to obtain 7.45 g of 3-propoxymethyl-7-amino-ceph-3-eme-4-carboxylic acid.

来源