反应 #52416

反应方程式

[4-(1-methoxycyclopropyl)-phenylethynyl]-trimethylsilane

Intermediate 60

[4-(1-methoxycyclopropyl)-phenylethynyl]-trimethylsilane

potassium carbonate

→

1-Ethynyl-4-(1-methoxycyclopropyl)-benzene

溶剂

methanol

反应条件

实验过程

Using General Procedure E; [4-(1-methoxycyclopropyl)-phenylethynyl]-trimethylsilane (Intermediate 60, 285.0 mg, 1.18 mmols) in methanol (10 mL) was treated with potassium carbonate (100.0 mg, 0.72 mmol) and stirred overnight at ambient temperature. The crude alkyne (220 mg, 100%) was used directly in the next reaction.

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