反应 #52334

反应方程式

6-methyl-2-nitro-pyridin-3-ol

→

title compound

2-Amino-6-methyl-pyridin-3-ol

溶剂

ethyl acetate

反应条件

后处理

1. 1
   过滤The mixture was filtered through Celite
2. 2
   洗涤washed with methanol/ethylacetate (5%)
3. 3
   洗涤The filtrate and washing
4. 4
   浓缩concentrated

实验过程

A mixture of 6-methyl-2-nitro-pyridin-3-ol (18.5 g, 0.120 mmol), 10% palladium on activated carbon (1.35 g), and ethyl acetate (240 mL) was hydrogenated for 3 days. The mixture was filtered through Celite and washed with methanol/ethylacetate (5%). The filtrate and washing were combined and concentrated to give the title compound (14.7 g, 99% yield) as a pale brown solid. 1H NMR (DMSO-d6) δ 9.19 (bs, 1H), 6.73 (d, 1H, J=7.6 Hz), 6.12 (d, 1H, J=7.6 Hz), 5.36 (bs, 2H), 2.15 (s, 3H).

来源