反应 #5226

反应方程式

4-Chloro-furo[3,4-c]quinoline-1,3-dione

sodium borohydride

→

4-Chloro-furo[3,4-c]quinolin-3(1H)-one

4-Chloro-furo[3,4-c]quinolin-1(3H)-one

溶剂

tetrahydrofuran

反应条件

后处理

1. 1
   workup.STIRRINGstirring
2. 2
   其他The reaction was then quenched with excess 6N HCl and water
3. 3
   浓缩concentrated in vacuo

实验过程

To a well stirred mixture of 4-Chloro-furo[3,4-c]quinoline-1,3-dione (1.9 g) in tetrahydrofuran (10 mL) was added sodium borohydride (400 mg) at 0° C. and stirring was continued for 2 h. The reaction was then quenched with excess 6N HCl and water, and concentrated in vacuo to afford 4-Chloro-furo[3,4-c]quinolin-3(1H)-one as a pink solid along with a small quantity of 4-Chloro-furo[3,4-c]quinolin-1(3H)-one which could be isolated by column chromatography on silica gel.

来源