反应 #51970

反应方程式

4-acetamidoacetophenone

bromine

→

title compound

收率 62.5%

N-[4-(2-bromoacetyl)phenyl]acetamide

收率 62.5%

溶剂

1,4-dioxane diethyl ether

反应条件

后处理

1. 1
   过滤The solid was collected by filtration
2. 2
   洗涤washed with diethyl ether
3. 3
   其他dried under high vacuum

实验过程

To a suspension of 4-acetamidoacetophenone (Lancaster, 5.32 g, 0.03 mol) in 1,4-dioxane/diethyl ether (100 mL, 1:2, v/v) was added bromine (1.53 mL, 0.03 mol) via a syringe. The reaction mixture was stirred at room temperature for 4 hours until the color of the mixture was changed from brown to white. The solid was collected by filtration, washed with diethyl ether, and dried under high vacuum to give the title compound as a white solid (4.8 g).

来源