反应 #516416

反应方程式

4′-Hydroxy[1,1′-biphenyl]-4-carboxylic acid

sulfuric acid

methanol

→

title compound

收率 95.0%

methyl 4′-hydroxy[1,1′-biphenyl]-4-carboxylate

收率 95.0%

反应条件

后处理

1. 1
   温度at reflux temperature for 24 hours
2. 2
   过滤filtered
3. 3
   洗涤The filter cake was washed with cold methanol (2×25 mL)
4. 4
   其他dried under reduced pressure

实验过程

4′-Hydroxy[1,1′-biphenyl]-4-carboxylic acid (5.0 g, 23.34 mmol, purchased from Aldrich Chemical Co.) and sulfuric acid (0.5 mL) in methanol (100 mL) were heated at reflux temperature for 24 hours. The mixture was allowed to cool to ambient temperature and then filtered. The filter cake was washed with cold methanol (2×25 mL) and dried under reduced pressure to provide the title compound (95% yield).

来源