反应 #51458

反应方程式

5-chlorocarbonylphthalid

morpholine

triethylamine

→

5-(4-morpholylcarbonyl)phthalid

溶剂

THF

THF

反应条件

后处理

1. 1
   其他THF is evaporated off in vacuo
2. 2
   温度The solution is cooled to 5° C.
3. 3
   洗涤washed with water (100 ml)

实验过程

A solution of 5-chlorocarbonylphthalid (39 g, 0.2 mole) in THF (400 ml) is added to a solution of morpholine (22 g. 0.25 mole) and triethylamine (26 g, 0.25 mole) in THF (200 ml) at 0° C. The mixture is stirred for 1 hour and is allowed to warm to room temperature. The reaction mixture is then poured into ice water ( 500 ml). THF is evaporated off in vacuo and the pH of the solution is adjusted to pH=2. The solution is cooled to 5° C. and the precipitated crystals are filtred off and washed with water (100 ml).

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