反应 #51284

反应方程式

3,5-Difluorophenylacetic acid

DMF

oxalyl chloride

→

3,5-difluorophenylacetyl chloride

溶剂

dichloromethane

反应条件

后处理

1. 1
   其他to give an oil which

实验过程

3,5-Difluorophenylacetic acid (30 g, 0.174 mol) (Aldrich) was dissolved in dichloromethane and this solution was cooled to 0° C. DMF (0.5 mL. catalytic) was added followed by the dropwise addition of oxalyl chloride (18 mL. 0.20 mol) over a 5 minute period. The reaction was stirred for 3 h and then rotoevaporated at reduced pressure to give an oil which was placed on a high vacuum pump for1 h to afford 3,5-difluorophenylacetyl chloride as a thin yellow oil. Other acid chlorides can be prepared in a similar manner.

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