反应 #51158

反应方程式

1-methyl-2,4-dioxo-6-(3-phenyl-prop-1-ynyl-1,4-dihydro-2H-2λ4-benzo[1,2,6]thiadiazin-3-ylmethyl]benzoic acid tert-butyl ester

4-[1,1,3-trioxo-7-(4-phenyl-but-1-ynyl)-3,4-dihydro-1H-1λ6-benzo[1,2,4]thiadiazin-2-ylmethyl]-benzoic acid tert-butyl ester

→

title compound

4-[1,1,3-Trioxo-7-(4-phenyl-but-1-ynyl)-3,4-dihydro-1H-1λ6-benzo[1,2,4]thiadiazin-2-ylmethyl]-benzoic acid tert-butyl ester

4-[1,1,3-trioxo-7-(4-phenyl-but-1-ynyl)-3,4-dihydro-1H-1λ6-benzo[1,2,4]thiadiazin-2-ylmethyl]-benzoic acid

反应条件

实验过程

When in procedure of Example 15, Step (5), 4-[1-methyl-2,4-dioxo-6-(3-phenyl-prop-1-ynyl-1,4-dihydro-2H-2λ4-benzo[1,2,6]thiadiazin-3-ylmethyl]benzoic acid tert-butyl ester was replaced with 4-[1,1,3-trioxo-7-(4-phenyl-but-1-ynyl)-3,4-dihydro-1H-1λ6-benzo[1,2,4]thiadiazin-2-ylmethyl]-benzoic acid tert-butyl ester, the title compound 4-[1,1,3-trioxo-7-(4-phenyl-but-1-ynyl)-3,4-dihydro-1H-1λ6-benzo[1,2,4]thiadiazin-2-ylmethyl]-benzoic acid was obtained as a white solid. 1H-NMR (CDCl3); δ 10.95 (s, 1H), 7.90 (d, 2H), 7.69 (s, 1H), 7.39 (m, 3H), 7.16 (m, 7H), 4.98 (s, 2H), 2.82 (t, 2H), and 2.60 (t, 2H). MS: M++1=461.0 Da

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