反应 #50681

反应方程式

1-(1-amino-1H-pyrrol-2-yl)ethanone

carbobenzyloxyglycine

DCC

→

product

收率 70.8%

Phenylmethyl-[2-[(2-acetyl-1H-pyrrol-1-yl)amino]-2-oxoethyl]carbamate

收率 70.8%

溶剂

DCM

反应条件

后处理

1. 1
   其他The precipitated DCU was removed by filtration
2. 2
   洗涤washed with ethyl acetate
3. 3
   浓缩The combined filtrates were concentrated
4. 4
   其他to give the crude product
5. 5
   其他Purification via flash column chromatography (silica gel, 10% EtOAc/hexane)

实验过程

To a stirred solution consisting of 1-(1-amino-1H-pyrrol-2-yl)ethanone (3.88 g) and carbobenzyloxyglycine (6.54 g) in dry DCM (115 ml) was added DCC (6.77 g) at 0° C. under nitrogen. The reaction mixture was allowed to stir at room temperature for 18 hours. The precipitated DCU was removed by filtration and washed with ethyl acetate. The combined filtrates were concentrated to give the crude product. Purification via flash column chromatography (silica gel, 10% EtOAc/hexane) afforded 6.98 g of the product as a solid, m.p. 109°-111° C.

来源