反应 #50670

反应方程式

charcoal

N-aminophthalimide

acetonylacetone

p-toluenesulfonic acid

→

desired product

2-(2,5-Dimethyl-1H-pyrrol-1-yl)-1H-isoindole-1,3(2H)dione

溶剂

toluene

反应条件

后处理

1. 1
   温度was heated
2. 2
   温度at reflux for 1 hour
3. 3
   过滤Filtration through a bed of celite
4. 4
   其他gave a solution which
5. 5
   浓缩upon partial concentration

实验过程

A stirred suspension of N-aminophthalimide (19.75 g), acetonylacetone (14.3 ml), p-toluenesulfonic acid (5 mg), and toluene (406 ml) was heated at reflux for 1 hour and cooled to room temperature. The reaction mixture was combined with another reaction mixture and the entire mixture decolorized with activated charcoal. Filtration through a bed of celite gave a solution which upon partial concentration resulted in crystallization of the desired product as a solid (11.0 g), m.p. 182.5°-183.5° C.

来源