反应 #50645

反应方程式

4-chloro-3-trifluoromethylcinnamonitrile

hydroxylamine hydrochloride

sodium carbonate

→

(E)-4-chloro-3-trifluoromethylcinnamamide oxime

收率 40.1%

溶剂

water

water

ethanol

反应条件

后处理

1. 1
   温度The mixture is heated
2. 2
   温度at reflux temperature until the reaction
3. 3
   其他(24 hours)
4. 4
   过滤is filtered off with suction
5. 5
   洗涤washed with a little water
6. 6
   其他dried

实验过程

12.1 g (0.05 mol) of 4-chloro-3-trifluoromethylcinnamonitrile are added to a solution consisting of 7.2 g (0.10 mol) of hydroxylamine hydrochloride and 7.3 g (0.10 mol) of sodium carbonate in 100 ml of water and 100 ml of ethanol. The mixture is heated at reflux temperature until the reaction is complete (24 hours) and the whole batch is subsequently stirred into 250 ml of water. The solid material which separates off during this process is filtered off with suction, washed with a little water and dried. 5.3 g (39.3% of theory) of (E)-4-chloro-3-trifluoromethylcinnamamide oxime are obtained.

来源