反应 #50624

反应方程式

Fumarate

2,3-dihydro-8-[3-(methanesulfonyloxy)propoxy]-7-methoxy-cyclopenta[c][1]-benzopyran-4(1H)-one

1-(2,3-dimethylphenyl)-piperazine

ethanol

→

8-{3-[4-(2,3-dimethylphenyl)-1-piperazinyl]propoxy}-2,3-dihydro-7-methoxy-cyclopenta[c][1]benzopyran-4(1H)-one

收率 84.0%

溶剂

acetone

反应条件

后处理

1. 1
   其他Method B (20 h at 60° C.)

实验过程

Method B (20 h at 60° C.); starting materials: 2,3-dihydro-8-[3-(methanesulfonyloxy)propoxy]-7-methoxy-cyclopenta[c][1]-benzopyran-4(1H)-one (example 82) and 1-(2,3-dimethylphenyl)-piperazine; yield 84%; fusion point 164°-166° C. (from ethanol). Fumarate: method E; yield 94%; fusion point 235°-237° C. (from acetone).

来源