反应 #50475

反应方程式

methyl 4-chlorosalicylate

methyl 3-bromopropionate

potassium carbonate

→

desired material

收率 102.6%

4- Chloro-2-(2-methoxy-1-methyl-2-oxoethoxy)benzoic acid, methyl ester

收率 102.6%

溶剂

dimethyl formamide

water

反应条件

后处理

1. 1
   萃取The mixture was extracted with ether
2. 2
   洗涤the organics were washed with water
3. 3
   其他The organic layer was dried
4. 4
   其他evaporated

实验过程

A solution of methyl 4-chlorosalicylate (5.0 g) in dimethyl formamide (10 ml) was treated sequentially with methyl 3-bromopropionate (4.0 g) and potassium carbonate (6.0 g). The mixture was stirred at room temperature for 18 hrs and diluted with water. The mixture was extracted with ether and the organics were washed with water. The organic layer was dried and evaporated to give the desired material (6.7 g) as a low melting solid. NMR: 7.8 (d, 1H), 7.2 (m 1H), 6.9 (m, 1H), 4.8 (q, 1H), 3.9 (s, 3H), 3.8 (s, 3H), 1.7 (d, 3H).

来源