反应 #50282

反应方程式

6,6-Dicarboethoxy-5,6,7,8-tetrahydro-2,4(1H,3H)-quinazolinedione

HCl

→

6-Carboethoxy-5,6,7,8-tetrahydro-2,4(1H ,3H)-quinazolinedione

溶剂

NaOH

反应条件

后处理

1. 1
   温度The solution was cooled in an ice bath
2. 2
   其他The precipitate that formed
3. 3
   其他was collected
4. 4
   温度refluxed in 20 ml of dimethylformamide (DMF) for 2 h
5. 5
   温度The reaction was cooled
6. 6
   其他the DMF removed in vacuo
7. 7
   workup.ADDITIONTo the resulting mixture 40 mL of water was added
8. 8
   其他the solid collected
9. 9
   其他dried

实验过程

A solution of of 6,6-Dicarboethoxy-5,6,7,8-tetrahydro-2,4(1H,3H)-quinazolinedione (25 g) in 1N NaOH (350 mL) was stirred at 40° C. for 35 min. The solution was cooled in an ice bath and acidified with 35 mL of concentrated HCl. The precipitate that formed was collected and refluxed in 20 ml of dimethylformamide (DMF) for 2 h. The reaction was cooled and the DMF removed in vacuo. To the resulting mixture 40 mL of water was added and the solid collected and dried to yield 6-Carboethoxy-5,6,7,8-tetrahydro-2,4(1H ,3H)-quinazolinedione.

来源