反应 #50277

ord-dedaec85bf7843bc866a0ca2b2d1f275

反应方程式

CCOCO[C@H]1CC[C@@]2(C)[C@H](CC[C@@H]3[C@@H]2CC[C@]2(C)C(O)(C#CC(=O)O)CC[C@]32O)C1
17-hydroxy-17-carboxyethynyl-3beta-ethoxymethoxy-14-hydroxy-5beta,14beta-androstane
C
charcoal
→
CCOCO[C@H]1CC[C@@]2(C)[C@H](CC[C@@H]3[C@@H]2CC[C@]2(C)C(O)(CCC(=O)O)CC[C@]32O)C1
17-hydroxy-17-(2-carboxyethyl)-3beta-ethoxymethoxy-14-hydroxy-5beta,14beta-androstane

反应物

CCOCO[C@H]1CC[C@@]2(C)[C@H](CC[C@@H]3[C@@H]2CC[C@]2(C)C(O)(C#CC(=O)O)CC[C@]32O)C1
17-hydroxy-17-carboxyethynyl-3beta-ethoxymethoxy-14-hydroxy-5beta,14beta-androstane
C
charcoal

试剂

[Pd]
palladium

溶剂

CCO
ethanol

反应条件

详细条件
See reaction.notes.procedure_details.

实验过程

A solution of 17-hydroxy-17-carboxyethynyl-3beta-ethoxymethoxy-14-hydroxy-5beta,14beta-androstane (30 mg), prepared as described in Example 12, in ethanol (5 ml), was hydrogenated at 2.72 atmosphere in a Parr apparatus in the presence of 10% palladium over charcoal.

来源

DOI: 10.6084/m9.figshare.5104873.v1专利: US05426179uspto-grants-1995_06