反应 #5023

反应方程式

ethanol

N-acetyl-5-bromo-7-nitroindoline

hydrochloric acid

→

compound

收率 32.2%

N-acetyl-7-amino-5-bromoindoline

收率 32.2%

溶剂

water

反应条件

后处理

1. 1
   温度to refluxing for 5 hours with vigorous stirring
2. 2
   过滤The reaction mixture was filtered by suction while hot
3. 3
   其他to remove insoluble matter
4. 4
   浓缩the filtrate thereof was concentrated
5. 5
   温度cooled

实验过程

To a mixed solution of ethanol (400 ml) and water (100 ml), were added N-acetyl-5-bromo-7-nitroindoline (133.1 g), iron powder (10 mesh; 75 g) and concentrated hydrochloric acid (5 ml), and the mixture was subjected to refluxing for 5 hours with vigorous stirring. The reaction mixture was filtered by suction while hot to remove insoluble matter, and then the filtrate thereof was concentrated and cooled on standing to give the intended compound 38.3 g (32.2%) as a brown needle crystal. M.P.: 154°-155° C.

来源