反应 #50108

反应方程式

2e

1,3-dichloro-3-fluoro-7-oxabicyclo[4.1.0]heptane

alcohol

1-methyl-2,2,6,6tetrachlorocyclohexanol

sodium hydroxide

→

epoxide

收率 95.5%

1,3,3-trichloro-2-methyl-7-oxabicyclo[4.1.0]heptane

收率 95.5%

溶剂

water

反应条件

后处理

1. 1
   其他reaction time
2. 2
   萃取ether extraction (5×40 cm3)

实验过程

The same procedure was employed as for the preparation of 2e in Example 17: it was performed with 3.97 g (15.75 mmol) of crude alcohol 1j, 20 cm3 of distilled water and 2.4 g (60 mmol) of sodium hydroxide; reaction time was 1 h 15 min; ether extraction (5×40 cm3); 3.29 g of epoxide 2h were obtained having a 95.5% yield based on the ketone (macrobore GC purity>99%)

来源