反应 #5009

ord-67807ba4f6aa49a6bfa5666d55bc49c7

反应方程式

Cc1ccccc1CC(=O)O
o-Tolylacetic acid
O=C1CCC(=O)N1Br
NBS
CC(C)(C#N)N=NC(C)(C)C#N
AIBN
→
CCOC(=O)Cc1ccccc1CBr
ethyl o-bromomethylphenylacetate

反应物

Cc1ccccc1CC(=O)O
o-Tolylacetic acid
O=C1CCC(=O)N1Br
NBS
CC(C)(C#N)N=NC(C)(C)C#N
AIBN

试剂

无

反应条件

详细条件
See reaction.notes.procedure_details.

实验过程

o-Tolylacetic acid was brominated with NBS and AIBN as described in Example 21 to give ethyl o-bromomethylphenylacetate, and this was reacted with triethyl phosphite as described in Example 2.

来源

DOI: 10.6084/m9.figshare.5104873.v1专利: US05242908uspto-grants-1993_09