反应 #5004

反应方程式

methyl 2-acetyl-6-[(4,6-dimethoxytriazin-2-yl)oxy]benzoate

methoxyamine hydrochloride

potassium acetate

methanol

→

aimed compound

收率 48.0%

methyl 2-[(4,6-dimethoxytriazin-2-y1)oxy]-6-[1-(N-methoxyimino)ethyl]benzoate

收率 48.0%

溶剂

water

反应条件

后处理

1. 1
   其他The resultant reaction liquor
2. 2
   萃取was extracted with ethyl acetate
3. 3
   洗涤After washing the extracted product with water
4. 4
   其他the washed product was dried
5. 5
   浓缩concentrated
6. 6
   其他to obtain an oily product
7. 7
   其他This was then purified by column chromatography

实验过程

0.9 of methyl 2-acetyl-6-[(4,6-dimethoxytriazin-2-yl)oxy]benzoate, 0.68 g of methoxyamine hydrochloride and 0.80 g of potassium acetate were added to 30 ml of methanol, and the resultant mixture was stirred for one day and one night at room temperature. The resultant reaction liquor was poured into water, and was extracted with ethyl acetate. After washing the extracted product with water, the washed product was dried and concentrated to obtain an oily product. This was then purified by column chromatography to obtain 0.47 g of the aimed compound (melting point=131° to 135° C.) at a yield of 48%.

来源