反应 #5002

反应方程式

methyl 2-[(4,6-dimethoxypyrimidin-2-yl)oxy]-6-hydroxyiminomethylbenzoate

ethyl 2-bromopropionate

→

aimed compound

收率 27.0%

methyl 2-[(4,6-dimethoxypyrimidin-2-yl)oxy]-6-[(1-ethoxycarbonylethyl)oxyiminomethyl)benzoate

收率 27.0%

溶剂

acetone

反应条件

后处理

1. 1
   workup.WAITto stand for one night at room temperature
2. 2
   其他reaction liquor
3. 3
   workup.DISTILLATIONthe acetone was distilled off under reduced pressure
4. 4
   其他The resultant product was purified by column chromatography

实验过程

2.0 g of methyl 2-[(4,6-dimethoxypyrimidin-2-yl)oxy]-6-hydroxyiminomethylbenzoate, 3 ml of ethyl 2-bromopropionate and 0.9 g of silver oxide (I) were place in a 50 ml eggplant type flask, and were allowed to stand for one night at room temperature. 10 ml of acetone and 10 g of silica gel were added to the resultant reaction liquor, and the acetone was distilled off under reduced pressure. The resultant product was purified by column chromatography to obtain 0.7 g of the aimed compound (refractive index=1.5261) at a yield of 27%.

来源