反应 #50011

反应方程式

ethyl acetate

Triethylamine

2,4-dichloro-6-fluoro-7-hydrazinobenzothiazole

Pivaloyl chloride

→

2,4-dichloro-6-fluoro-7-[N-(2,2-dimethylpropanoyl)hydrazino]benzothiazole

溶剂

toluene

反应条件

后处理

1. 1
   洗涤washed with aqueous sodium hydrogen carbonate and water
2. 2
   干燥dried over magnesium sulfate
3. 3
   浓缩concentrated
4. 4
   其他The residue was purified by column chromatography

实验过程

2.6 ml Triethylamine was added to a solution of 4.8 g 2,4-dichloro-6-fluoro-7-hydrazinobenzothiazole in 38 ml toluene. 2.4 ml Pivaloyl chloride was added dropwise and the mixture stirred for 2 hours at room temperature. It was then treated with ethyl acetate and washed with aqueous sodium hydrogen carbonate and water, dried over magnesium sulfate and concentrated. The residue was purified by column chromatography. Yield: 1.36 g=21% of theory

来源