反应 #4996

反应方程式

3-(trichloromethyl)-5-[(2,4-dichlorophenoxy)methyl]-1,2,4-oxadiazole

methanol

ammonia

→

desired product

收率 50.9%

3-(iminomethoxymethyl)-5-[(2,4-dichlorophenoxy)methyl]-1,2,4-oxadiazole

收率 50.9%

反应条件

后处理

1. 1
   其他of bubble at 0° C.
2. 2
   其他After evaporation of methanol, water
3. 3
   workup.ADDITIONwas added to the residue
4. 4
   萃取The aqueous solution was extracted with ethylacetate
5. 5
   其他After evaporation of ethylacetate
6. 6
   其他the residue was purified by column chromatography(hexane:ethylacetate)

实验过程

2.17 g of 3-(trichloromethyl)-5-[(2,4-dichlorophenoxy)methyl]-1,2,4-oxadiazole was added to 50 ml of methanol. An excess of ammonia gas was added with formation of bubble at 0° C. and then the mixture was stirred at room temperature for 4 hours. After evaporation of methanol, water was added to the residue. The aqueous solution was extracted with ethylacetate. After evaporation of ethylacetate, the residue was purified by column chromatography(hexane:ethylacetate) to provide 0.92 g of the desired product(yield: 50.9%).

来源