反应 #4995

反应方程式

3-propylcarbonyl-5-[(2,4-dichlorophenoxy)methyl]-1,2,4-oxadiazole

aluminum isopropoxide

→

desired product

收率 54.0%

3-(1-hydroxybutyl)-5-[(2,4-dichlorophenoxy)methyl]-1,2,4-oxadiazole

收率 54.0%

溶剂

isopropanol

反应条件

后处理

1. 1
   温度The mixture was heated
2. 2
   温度to reflux for 48 hours
3. 3
   其他After evaporation of isopropanol, water
4. 4
   workup.ADDITIONwas added to the residue
5. 5
   萃取The aqueous solution was extracted with ethylacetate
6. 6
   其他After evaporation of ethylacetate
7. 7
   其他the residue was purified by column chromatography(hexane: ethylacetate=3:2)

实验过程

0.316 g of 3-propylcarbonyl-5-[(2,4-dichlorophenoxy)methyl]-1,2,4-oxadiazole and 0.20 g of aluminum isopropoxide were added to 10 ml of isopropanol. The mixture was heated to reflux for 48 hours. After evaporation of isopropanol, water was added to the residue. The aqueous solution was extracted with ethylacetate. After evaporation of ethylacetate, the residue was purified by column chromatography(hexane: ethylacetate=3:2) to provide 0.17 g of the desired product(yield: 54.0%).

来源