反应 #4993

反应方程式

3-ethoxycarbonyl-5-[(2,4-dichlorophenoxy)methyl]-1,2,4-oxadiazole

ethylmagnesium bromide

HCl

→

desired product

收率 83.0%

3-ethylcarbonyl-5-[(2,4-dichlorophenoxy)methyl]-1,2,4-oxadiazole

收率 83.0%

溶剂

tetrahydrofuran

反应条件

后处理

1. 1
   萃取After the resulted product was extracted with ether
2. 2
   浓缩concentrated
3. 3
   其他it was purified by column chromatography(hexane:ethylacetate=4:1)

实验过程

0.95 g of 3-ethoxycarbonyl-5-[(2,4-dichlorophenoxy)methyl]-1,2,4-oxadiazole was added to 30 ml of tetrahydrofuran. The mixture was cooled to -78° C., and then 3 ml of ethylmagnesium bromide (2M solution) was added dropwise. After the mixture was stirred at -78° C. for 1 hour, it was poured into cold aqueous 5% HCl solution. After the resulted product was extracted with ether and concentrated, it was purified by column chromatography(hexane:ethylacetate=4:1) to obtain 0.75 g of the desired product(yield: 83.0%).

来源