反应 #49908

反应方程式

N'-t-butyl-N,N'-dibenzoylhydrazine

Methoxymethyl chloride

→

N-methoxymethyl-N'-t-butyl-N,N'-dibenzoylhydrazine

溶剂

toluene

反应条件

后处理

1. 1
   其他The layers were separated
2. 2
   洗涤the toluene layer was washed several times with water (until the water washes
3. 3
   干燥The toluene solution was dried over anhydrous magnesium sulfate
4. 4
   其他the toluene removed under vacuum

实验过程

N'-t-butyl-N,N'-dibenzoylhydrazine (2 g, 0.007M) was stirred at room temperature in a two phase system of toluene-50% sodium hydroxide with 100 mg of phase transfer catalyst (tetra-n-butylammonium hydrogen sulfate). Methoxymethyl chloride (1.2 g, 0.015M) was added dropwise and the mixture was stirred 3 hours. The layers were separated and the toluene layer was washed several times with water (until the water washes were neutral). The toluene solution was dried over anhydrous magnesium sulfate and the toluene removed under vacuum to afford N-methoxymethyl-N'-t-butyl-N,N'-dibenzoylhydrazine as a thick oil.

来源