反应 #49751

反应方程式

cyclopentyl bromide

Ethyl N-(2-fluoro-4-chloro-5-methoxycarbonyloxyphenyl)carbamate

potassium carbonate

hydrochloric acid

→

ethyl N-(2-fluoro-4-chloro-5-cyclopentyloxyphenyl)carbamate

溶剂

ethanol

反应条件

后处理

1. 1
   温度while refluxing
2. 2
   其他After completion of the reaction
3. 3
   萃取extracted with ethyl acetate (50 ml×3 times)
4. 4
   其他The organic layer was dried
5. 5
   浓缩concentrated under reduced pressure

实验过程

Ethyl N-(2-fluoro-4-chloro-5-methoxycarbonyloxyphenyl)carbamate (1.45 g, 4.97 mmol) prepared by the process described in Reference Example 1 and a solution of potassium carbonate (1.03 g, 7.46 mmol) in ethanol (5.0 ml) were stirred for 1 hour while refluxing, and then cyclopentyl bromide (1.11 g, 7.46 mmol) was added thereto, followed by further stirring for 2 hours. After completion of the reaction, the mixture was poured into 1N hydrochloric acid (50 ml), and extracted with ethyl acetate (50 ml×3 times). The organic layer was dried, and concentrated under reduced pressure to obtain ethyl N-(2-fluoro-4-chloro-5-cyclopentyloxyphenyl)carbamate as grey white crystals (1.41 g, 4 69 mmol 94.4% yield) The spectral data and the like are as shown in Reference Example 1.

来源