反应 #49726

反应方程式

3-cyclopropyl-1-(2-fluoro-4-methylsulphonylphenyl)-propan-1,3-dione

triethyl orthoformate

acetic anhydride

→

3-cyclopropyl-2-ethoxymethylene-1-(2-fluoro-4-methylsulphonylphenyl)-propan-1,3-dione

收率 99.3%

反应条件

后处理

1. 1
   温度heated
2. 2
   温度at reflux for 4 hours
3. 3
   其他The mixture was evaporated to dryness
4. 4
   workup.ADDITIONXylene was added
5. 5
   其他the mixture was re-evaporated

实验过程

A mixture of 3-cyclopropyl-1-(2-fluoro-4-methylsulphonylphenyl)-propan-1,3-dione (7.4 g), triethyl orthoformate (8.5 g) and acetic anhydride was stirred and heated at reflux for 4 hours. The mixture was evaporated to dryness. Xylene was added and the mixture was re-evaporated to give 3-cyclopropyl-2-ethoxymethylene-1-(2-fluoro-4-methylsulphonylphenyl)-propan-1,3-dione (8.8 g) as a red oil which was not further purified.

来源