反应 #49711

反应方程式

methyl 4-hydroxybenzoate

octadecylbromide

potassium carbonate

→

methyl 4-octadecyloxybenzoate

收率 45.4%

溶剂

2-butanone

反应条件

后处理

1. 1
   温度was heated
2. 2
   温度at reflux for 16 hours
3. 3
   其他The solvent was then removed until 125 ml of 2-butanone
4. 4
   其他had been collected
5. 5
   温度While it was still warm
6. 6
   workup.ADDITIONthe remaining material was poured into methanol (400 ml)
7. 7
   过滤The product was filtered
8. 8
   其他recrystallized from 2000 ml of methanol

实验过程

A mixture containing methyl 4-hydroxybenzoate (45.6 g), octadecylbromide (100 g), and potassium carbonate (41.4 g) in 2-butanone (200 ml) was heated at reflux for 16 hours. The solvent was then removed until 125 ml of 2-butanone had been collected. While it was still warm, the remaining material was poured into methanol (400 ml). The product was filtered and recrystallized from 2000 ml of methanol to give methyl 4-octadecyloxybenzoate (55 g).

来源