反应 #4968

反应方程式

4-ethoxyphenylacetylene

3,4-difluoroiodobenzene

triethylamine

→

3,4-difluoro-4'-ethoxytolan

溶剂

methyl tert.-butyl ether

反应条件

后处理

1. 1
   过滤filtered with suction
2. 2
   其他the solution is evaporated
3. 3
   其他Purification
4. 4
   其他by chromatography and/or crystallization

实验过程

0.4 mmol of bis(triphenylphosphine)palladium(II) chloride and 0.2 mmol of CuI are added at room temperature to a mixture of 0.02 m of 4-ethoxyphenylacetylene, 0.02 m of 3,4-difluoroiodobenzene and 50 ml of triethylamine. The reaction mixture is stirred at room temperature for 2 hours, diluted with 100 ml of methyl tert.-butyl ether and filtered with suction, and the solution is evaporated. Purification by chromatography and/or crystallization gives 3,4-difluoro-4'-ethoxytolan, K 67 I, Δε=11.18.

来源