反应 #49475

反应方程式

7-amino-4-(4-tert-butyldimethylsilyloxy-3-methoxyphenyl)isoindolinone

potassium iodide

iodine

tert-butyl nitrate

→

7-iodo-4-(4-tert-butyldimethylsilyloxy-3-methoxyphenyl)isoindolinone

收率 62.0%

溶剂

acetonitrile

反应条件

后处理

1. 1
   其他followed by purification by preparative thin-layer chromatography (chloroform/acetonitrile=5/1)

实验过程

In a similar manner to Step 4 of Example 140, 7-amino-4-(4-tert-butyldimethylsilyloxy-3-methoxyphenyl)isoindolinone (43.0 mg, 0.110 mmol) was dissolved in acetonitrile (6 mL), and the solution was treated with potassium iodide (29.2 mg, 0.176 mmol), copper iodide (33.5 mg, 0.896 mmol), iodine (44.7 mg, 0.896 mmol) and tert-butyl nitrate (0.059 mL, 0.50 mmol), followed by purification by preparative thin-layer chromatography (chloroform/acetonitrile=5/1) to obtain 7-iodo-4-(4-tert-butyldimethylsilyloxy-3-methoxyphenyl)isoindolinone (33.8 mg, yield 62%).

来源