反应 #49372

反应方程式

4-methoxymethoxy-3-hydroxy-7-iodo-2-(1-methyl-1-phenylethyl)isoindolinone

trifluoroacetic acid

triethylsilane

→

4-hydroxy-7-iodo-2-(1-methyl-1-phenylethyl)isoindolinone

收率 59.0%

4-methoxymethoxy-7-iodo-2-(1-methyl-1-phenylethyl)isoindolinone

收率 27.0%

溶剂

nitromethane

反应条件

后处理

1. 1
   其他followed by purification by flash column chromatography (chloroform/methanol=100/0, 99/1)

实验过程

In a similar manner to Step 4 of Example 16, 4-methoxymethoxy-3-hydroxy-7-iodo-2-(1-methyl-1-phenylethyl)isoindolinone (500 mg, 1.10 mmol) was dissolved in nitromethane (25 mL), and the solution was treated with trifluoroacetic acid (0.525 mL, 6.82 mmol) and triethylsilane (0.527 mL, 3.30 mmol), followed by purification by flash column chromatography (chloroform/methanol=100/0, 99/1) to obtain 4-hydroxy-7-iodo-2-(1-methyl-1-phenylethyl)isoindolinone (257 mg, yield 59%) and 4-methoxymethoxy-7-iodo-2-(1-methyl-1-phenylethyl)isoindolinone (131 mg, yield 27%).

来源