反应 #49355

反应方程式

4-methoxy-3-hydroxy-7-iodo-2-(1-methyl-1-phenylethyl)isoindolinone

trifluoroacetic acid

triethylsilane

→

4-methoxy-7-iodoisoindolinone

收率 78.0%

溶剂

nitromethane

反应条件

后处理

1. 1
   过滤The obtained solid was collected by filtration
2. 2
   洗涤washed with ethyl acetate
3. 3
   其他The obtained solid was dried under reduced pressure

实验过程

In a similar manner to Step 4 of Example 16, 4-methoxy-3-hydroxy-7-iodo-2-(1-methyl-1-phenylethyl)isoindolinone (2.50 g, 5.91 mmol) was dissolved in nitromethane (100 mL), and the solution was treated with trifluoroacetic acid (4.50 mL, 59.1 mmol) and triethylsilane (1.90 mL, 11.8 mmol). The obtained solid was collected by filtration and washed with ethyl acetate. The obtained solid was dried under reduced pressure to obtain 4-methoxy-7-iodoisoindolinone (1.32 g, yield 78%).

来源