反应 #49274

反应方程式

3-amino-6-bromophthalimide

Iodine

sodium thiosulfate

→

3-amino-4-iodo-6-bromophthalimide

收率 96.0%

溶剂

ethanol

反应条件

后处理

1. 1
   萃取extracted with ethyl acetate
2. 2
   洗涤The organic layer was washed with 0.5 mol/L hydrochloric acid and saturated brine
3. 3
   干燥dried over anhydrous sodium sulfate
4. 4
   其他The solvent was evaporated under reduced pressure
5. 5
   其他the residue was purified by slurry

实验过程

Iodine (6.29 g, 24.8 mmol) was dissolved in ethanol (225 mL), and the solution was added with silver sulfate (3.87 g, 12.4 mmol) and 3-amino-6-bromophthalimide (3.00 g, 12.4 mmol), followed by stirring at room temperature for 23 hours. The reaction mixture was added with 10% aqueous sodium thiosulfate solution and extracted with ethyl acetate. The organic layer was washed with 0.5 mol/L hydrochloric acid and saturated brine and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure, the residue was purified by slurry using hexane and methanol to obtain 3-amino-4-iodo-6-bromophthalimide (4.3 g. yield 96%).

来源