反应 #49172

反应方程式

Compound 4a

(6-{2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-pyrrolidin-1-yl}-6-oxo-hexyl)-carbamic acid benzyl ester

→

compound 5

收率 91.4%

6-Amino-1-{2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-pyrrolidin-1-yl}-hexan-1-one

收率 91.4%

溶剂

ethyl acetate

反应条件

后处理

1. 1
   其他purged with argon
2. 2
   workup.ADDITIONTo the solution was added 10% palladium on carbon (2 g)
3. 3
   其他The flask was purged with hydrogen 2 times
4. 4
   过滤The reaction mixture was filtered through a pad of Celite
5. 5
   洗涤washed with ethyl acetate
6. 6
   浓缩The combined organic layer was concentrated under reduced pressure

实验过程

Compound 4a (14.5 g, 21.7 mmol) was dissolved in ethyl acetate (100 mL) and purged with argon. To the solution was added 10% palladium on carbon (2 g). The flask was purged with hydrogen 2 times and stirred further at room temperature under hydrogen atmosphere for overnight. The disappearance of the starting material was confirmed by the TLC. The reaction mixture was filtered through a pad of Celite and washed with ethyl acetate. The combined organic layer was concentrated under reduced pressure to afford compound 5 (10.56 g, 91%) as white solid. This was used as such for the next step.

来源